National Taiwan Normal University Course Outline
 Fall , 2021

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Please respect the intellectual property rights, and shall not copy the textbooks arbitrarily.

I.Course information
Serial No. 1210 Course Level Master / PhD
Course Code OEC8155 Chinese Course Name 生醫晶片製程技術
Course Name Bio-Chips Manufacturing Technology
Department Graduate Institute of Electro-optical Engineering
Two/one semester 1 Req. / Sel. Sel.
Credits 3.0 Lecturing hours Lecture hours: 3
Prerequisite Course ◎1. This is a cross-level course and is available for junior and senior undergraduate students, master's students and PhD students. 2. If the listed course is a doctroal level course, it is only available for master's students and PhD students.
Comment
Course Description
Day & Class Period/Location Fri. 7-9 Gongguan AP0-01
Curriculum Goals Corresponding to the Departmental Core Goal
1.　引導學生進入生醫晶片與半導體晶片專題領域，使學生建 立生醫晶片專長，教導學生如何將這些原理,技術與器件應用於 生醫晶片科技檢驗。 Master:
　1-1 Understand the basic knowledge of optoelectronic engineering, optoelectronics and optoelectronics.
　1-2 Have the hands-on ability to perform basic experiments in optoelectronics.
　1-3 Able to analyze and interpret experimental data.
　1-4 Ability to identify and solve problems independently.
Doctor:
　1-1 Understand the basic knowledge of optoelectronic engineering, optoelectronics and optoelectronics.
　1-2 Have the hands-on ability to perform basic experiments in optoelectronics.
　1-3 Able to analyze and interpret experimental data.
　1-4 Ability to identify and solve problems independently.
2.　訓練學生獨立實驗能力與表達能力，具備分析及論證議題 的能力。 Master:
　2-1 Have the ability to self-study, learn, and develop new knowledge of optoelectronic technology.
　2-2 Have teamwork and responsible working attitude.
　2-3 Have the ability to communicate rationally and express clearly.
　2-4 Have the ability to understand the development status of the optoelectronic industry.
Doctor:
　2-1 Have the ability to self-study, learn, and develop new knowledge of optoelectronic technology.
　2-2 Have teamwork and responsible working attitude.
　2-3 Have the ability to communicate rationally and express clearly.
　2-4 Have the ability to understand the development status of the optoelectronic industry.
3.　瞭解製程設備工作的目的，瞭解半導體知識的本質，以及 瞭解生醫晶片為社會帶來的福祉效益。 Master:
　3-1 Can maintain mature and stable emotions.
　3-2 Has a high degree of frustration tolerance.
　3-3 Ability to think systematically and logically.
Doctor:
　3-1 Can maintain mature and stable emotions.
　3-2 Has a high degree of frustration tolerance.
　3-3 Ability to think systematically and logically.
4.　具備獨立思考與創新能力的養成。 Master:
　4-1 Have the spirit of honesty and non-fraud.
　4-2 Has a skeptical and intellectual attitude.
　4-3 Awareness of respecting intellectual property rights.
Doctor:
　4-1 Have the spirit of honesty and non-fraud.
　4-2 Has a skeptical and intellectual attitude.
　4-3 Awareness of respecting intellectual property rights.

II. General Syllabus
Instructor(s) CHIU, Nan-Fu/ 邱南福
Schedule

國立臺灣師範大學課程綱要

一、課程基本資料（任課教師不可異動部分，同一課程名稱此部分應相同）

課程代碼

OEC8155

課程名稱

生醫晶片製程技術

應科大樓B1

英文名稱

Bio-Chips Manufacturing Technology

週五 (7-9)

全/半年

半年

必/選修

選修

學分數

3

每週授課時數

3

開課系級

碩博

先修課程

 

課程簡介

  1. 教習進階生醫晶片製程技術及原理，主題包含半導體製程、IC CMOS標準製程、製程設備工作原理及技術、生物培養流程、相容性製程技術、異質整合技術、生化修飾技術及原理、生醫感測器原理等。
  2. 實務製作：讓學生學習儀器操作，生醫晶片實務製作，生物細胞的培養，光電生物分子定量定性的檢測等。
  3. 光學系統的架設：量測系統，光電生理量測系統教學。

Biochips, or microchips, are small, wafer-like components manufactured from substrates such as silicon, fused quartz, soda glass and plastic. Substrates are selected on the basis of chemical structure and physical attributes, such as conductivity, pliability and surface topography. Techniques have been developed for microchip manipulation, including techniques to produce physical structures (chambers and channels). For example microfabricators have used photolithographic or reactive ion-etching methods, embossing, microinjection moulding, micromilling, and x-ray or e-beam etching and scanning tunnelling microscope. Techniques to produce microarrays of test areas have also been described including physical deposition or synthetic techniques, such as ink-jet printing and light directed combinatorial chemistry. Biochip technology can be adapted and utilised for almost any laboratory application and covers all scientific disciplines including immunology, clinical chemistry and even DNA profiling.

課程目標

對應系所核心能力

1

引導學生進入生醫晶片與半導體晶片專題領域，使學生建立生醫晶片專長，教導學生如何將這些原理,技術與器件應用於生醫晶片科技檢驗。

1-1瞭解光電工程、光電電子與光電電磁等基本知識。
1-2具有執行光電基礎實驗的動手操作能力。
1-3能夠分析與詮釋實驗數據。
1-4具備發現問題與獨立解決問題的能力。

2

訓練學生獨立實驗能力與表達能力，具備分析及論證議題的能力。

2-1具備對光電科技新知自我進修、學習、與發展的能力。

2-2具備團隊合作與負責任的工作態度。

2-3具有理性溝通、清楚表達的能力。

2-4具有理解光電產業發展現況的能力。

3

瞭解製程設備工作的目的，瞭解半導體知識的本質，以及瞭解生醫晶片為社會帶來的福祉效益。

3-1能維持成熟穩定的情緒。

3-2具備高度挫折耐受力。

3-3具有系統化及邏輯思考的能力。

4

具備獨立思考與創新能力的養成。

4-1具有誠實不造假的精神。

4-2具有抱持懷疑的求知態度。

4-3具有尊重智慧財產權的認知。

         

 

二、教學大綱（任課教師可異動部分）

授課教師

邱南福

教學進度與主題【授課方式：16+2週】（可說明每週進度）

110學年度授課方式採「16+2週」，即「授課16週＋2週彈性教學（第17、18週）」。
【授課16週】
精實課程，於1～16週依排定時間授課，完成學期教學目標。
【彈性教學2週】
1.彈性補充教學(實作與專題補充教學或自主學習)等方式辦理。

 

上課網址Googlle meet：  meet.google.com/jkx-zsds-mpp

授碼請來信索取

授課資訊將統一公告於Moodle平台，請選課學生自行查閱。

Facebook: (2021)-110-1 生醫晶片製程技術

 

週

課程內容(課程內容會依本學期修課學生的能力也做適度調整!)

 

1 week

2021/09/24

課程介紹-分組 Course Introduction

On-line

2 week

2021/10/01

Overview of Biosensor and Review of biophotonics

生醫感測技術之工作原理、製作及應用及產業發展

On-line

3 week

2021/10/08

 

Review Biosensor 生醫晶片介紹 (細胞cell, 蛋白質 Protein , DNA)

On-line

4 week

2021/10/15

奈米光學及電漿子學之介紹 (Introduction of Nano optics and Plasmonics)

應科大樓B1

5 week

2021/10/22

教學:奈米金合成備製

Synthesis of Gold nanoparticles (AuNPs)

應科大樓B1

6 week

2021/10/29

光譜設備教學(spectrum equipment teaching)

光電314室

7 week

2021/11/05

專題製作:(奈米金之合成製作)-1

Thematic production-(AuNPs synthetic production and measurement)-1

專題製作:(Au film製作)-2

光電314室

8 week

2021/11/12

專題製作:奈米金之光學特性與技術 (Optical properties and technology in AuNPs/Au film)量測 

光電314室

9 week

2021/11/19

專題製作:合成及生物的修飾技術

Synthesis and biological modification technology 

光電314室

10 week

2021/11/26

專題製作: (晶片之製作及量測分析)-1

Thematic production- (Biosensor fabrication and measurement analysis) -1

光電314室

11 week

2021/12/03

專題製作: (晶片之製作及量測分析)-2

Thematic production- (Biosensor fabrication and measurement analysis) -2

光電314室

12 week

2021/12/10

校慶放假 (University Events Day)

 

13 week

2021/12/17

專題製作: (檢測蛋白質濃度技術)-1

Thematic production- (Detection of protein concentration at SPR system) -1

光電314室

14 week

2021/12/24

專題製作: (檢測蛋白質濃度技術)-2

Thematic production- (Detection of protein concentration at SPR system) -2

光電314室

15 week

2021/12/31

National Day holiday (National Day holiday)

開國紀念日補假1日

 

16 week

2022/01/07

期末口頭報告 (Final oral report) (40%)-1 (英文)

(如修課人數過多,將分組於第17週報告)

分組

應科大樓B1

17 week

2022/01/14

期末口頭報告 (Final oral report) (40%)-2(英文)

彈性補充教學(實驗補充教學或自主學習)

分組

應科大樓B1

18 week

2022/01/21

學期專題書報 (special paper report) (60%)

彈性補充教學(實驗補充教學或自主學習)

 

 

 

課程內容會依本學期修課學生的領域及能力做適度調整!

如因疫情進入三級警戒以上，課程將配合學校改為線上講課。另外，實驗相關課程將提供影片或停止實體實驗課。

 

 

教學方法

方式

說明

▓  講述法

講述基本原理,現象與技術之應用等,討論國內與國際間之現況與發展趨勢

  • 討論法

 

  • 問題解決教學

 

  • 合作學習

 

▓  實驗/實作

專題實驗:每位同學必須完成一件實驗的觀測及製作

(以組為單位/分工合作)

  • 實地考察、參訪

 

  • 媒體融入教學

 

▓  專題研究

專題實驗:每位同學必須完成一件實驗的觀測及製作

(以組為單位/分工合作)

  • 其他：

 

評量方法

方式

百分比

說明

  • 作業

 

 

  • 期中考

 

 

  • 期末考

 

 

  • 課堂討論參與

 

 

  • 出席

 

 

▓  報告

40%

期末口頭報告,專題實驗討論與口頭報告30分鐘(英文)。訓練系統化及邏輯思考的能力。

  • 成果展覽

 

 

▓  專題

60%

實驗教學與專題實驗。訓練抱持懷疑的求知態度與尊重智慧財產權的認知。自我學習回顧報告，主題式文獻報告，專題實驗

  • 其他：

 

 

參考書目

  1. Jing Cheng, Larry J. Kricka, Biochip Technology, CRC Press, 2003, ISBN 0203305043.
  2. R. Edwin Oosterbroek, Albert Berg ,Lab-on-a-chip: Miniaturized Systems for (bio)chemical Analysis and Synthesis, Elsevier, 2003, ISBN 0444511008
  3. Frank A. Gomez , Fundamentals of microfluidics and lab on a chip for biological analysis and discovery, John Wiley & Sons, 2008, ISBN 0470074833.
  4. 自製教材
    

 


教學進度與主題附件
Instructional Approach
Methods Notes
Formal lecture 講述基本原理,現象與技術之應用等,討論國內與國際間之現 況與發展趨勢
Lab/Studio 專題實驗:每位同學必須完成一件實驗的觀測及製作
Case studies 專題實驗:每位同學必須完成一件實驗的觀測及製作
Grading assessment
Methods Percentage Notes
Presentation 40 % 期末口頭報告,專題實驗討論與口頭報告30分鐘。訓練系統化及邏輯思考的能力。
Case study reports 60 % 實驗教學與專題實驗。訓練抱持懷疑的求知態度與尊重智慧財產權的認知。自我學習回顧報告，主題式文獻報告，專題實驗
Required and Recommended Texts/Readings with References
  1. Jing Cheng, Larry J. Kricka, Biochip Technology, CRC Press, 2003, ISBN 0203305043.
  2. R. Edwin Oosterbroek, Albert Berg ,Lab-on-a-chip: Miniaturized Systems for (bio)chemical Analysis and Synthesis, Elsevier, 2003, ISBN 0444511008
  3. Frank A. Gomez , Fundamentals of microfluidics and lab on a chip for biological analysis and discovery, John Wiley & Sons, 2008, ISBN 0470074833.
  4. 自製教材


參考書目附件

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